Discussion on Application of microwave drying sterilizer in pill production
In this paper, the microwave drying equipment was used to carry out pilot-scale tests on three different types of pills, water pills, honey pills and concentrated pills. The results show that microwave can heat the pills and heat them evenly. It has expansion effect on pills, fast drying speed and good sterilization effect of sterilization dryer. However, in the application of pill production, it should be noted that microwave can prolong the dissolution time of pill varieties with more animal and oil components.
Tianbaojing granule is composed of 9 traditional Chinese medicines, such as cinnamon, tulip, rhubarb and phellodendron. It is clinically used to treat male semen non-liquefaction and other symptoms. Both tulip and cinnamon in the prescription contain volatile oil. Because the volatile oil has strong volatility, when exposed to light and heat, it is not stable . The inclusion of the volatile oil with beta-cyclodextrin (beta-CD) can make it powdered, improve its stability and play its therapeutic role better. In order to improve the oil content of inclusion complex and the utilization ratio of volatile oil, many factors affecting the oil content of inclusion complex and the utilization ratio of volatile oil were investigated, and the better inclusion process conditions were determined by optimization.
1.1 Instrument 2201 Ultraviolet Spectrophotometer (Japan Island Essence); KS-500D Ultrasound Cleaner (Ningbo Kesheng Instrument Factory): HJ-7 Six-unit Constant Temperature Magnetic Stirrer (Jintan Huafeng Instrument Factory); Differential Scanning Calorimeter (DSC, Germany NETZSCH Company); ZK-82BB Electrothermal Vacuum Dryer (Shanghai Experimental Instrument General Factory); Volatile Oil Determination Apparatus.
1.21.2 Cinnamon and tulip were purchased from the First Affiliated Hospital of Medical College of Shihezi University, and were identified as genuine by Shihezi Institute of Pharmaceutical Inspection. Cinnamon is the dried bark of Cinnamomum cassia CinnamomuncassiaPresl. Tulip is Curcuma kwangsiensis S. G. Leeet C. Liang; beta-CD (Beijing Oboxin Biotechnology Co., Ltd.); other reagents are analytical pure.
The extraction method of 2.1.2 by prescription than weigh cinnamon and turmeric, mixed and crushed with steam distillation to extract volatile oil reserve. Note: the following instructions are all volatile oils extracted from the mixture of cinnamon and Curcuma. 2.1.3 blank recovery test precise amount of volatile oil of 1 mL, the volatile oil, and distilled water 200 mL, a method for the determination of oil operation according to "China Pharmacopoeia" 2000 edition appendix essential, calculation of recovery rate of blank. Blank recovery = recovery oil / oil added * 100%. The average recovery rate was 80% (n=3). 2.1.4 inclusion of volatile oil extracted from the inclusion of the volatile oil, the experiments were performed according to 2.1.3 method, calculate the inclusion rate of volatile oils and the utilization rate of oil.
Determination of volatile oil content  respectively cinnamon, turmeric, crushed the No. 2 sieve, the volatile oil, according to the "China" Pharmacopoeia of 2000 edition appendix in the determination of volatile oil extraction (n=3), calculate the content of volatile oil. Results: the content of volatile oil in Cinnamomum cassia was 1.36%, and the content of volatile oil in Curcuma was 0.19%.